DMT Information
¨ ¨DMT, N,N-diemethyltryptamine, Nigerine, desoxybufotenine, 3-(2-dimethylaminoethyl)-indole is a white, pungent-smelling, crystalline solid. ¨It has melting point of 49-50 degrees Celsius, hydrochloride salt hygroscopic, picratem.p. 171-172 degrees Celsius and methiodidem.p. 215-216 degrees Celsius. ¨It is insoluble in water, but soluble in organic solvents and aqueous acids.1acids.1
¨N,N-DMT use has been documented as early as the 8th Century AD in snuffs found in burial sites, but its use is believed to be much older. ¨Cohoba snuffs (from the Yopo tree) were documented in Columbia in the 16th through 19th Centuries. N,N-DMT and 5-MeO-DMT were finally identified as the active constituents of cohoba in the early 1950s ¨In 1954 N,N-DMT was isolated as an active ingredient in A. peregrina.2
Onset
When smoked, DMT generally reaches full effects within 10-60 seconds of inhalation.
Duration
The primary effects of N,N-DMT last approximately 5-20 minutes when smoked. For many people there is an additional period of time (1-2 hrs) before fully returning to baseline. Some people find DMT experiences difficult to integrate and experience unsettling thoughts and feelings for days after use.
Onset
When DMT is consumed in an Ayahuasca brew; Depending on how much and how recently one has eaten and individual variation, effects begin between 20 and 60 minutes after ingestion.
Duration
With lower doses, effects last shorter, larger doses last longer, with the range being from 2-6 hours of peak effects with 1-8 hours after of lingering effects, depending on dosage and individual user variation.
Physiological Mechanisms
Anatomical:
Resembles LSD, but mimics sympathetic reflex symptoms like dilated pupils, heightened blood pressure, and increased pulse rate are more common and more intense.
Action in the brain:
DMT much like LSD has it’s effect on the serotonergic system. Binding the 5HT2a & 5HT2c receptor cites.
Endogenous Neurochemical:
DMT is one the only endogenous psychedelic known, meaning is produced within the body. While it’s role in the brain is unknown , it has been speculated that DMT is released by the pineal gland.
